The mechanisms by which most receptor protein‐tyrosine kinases (RTKs) transmit signals are now well established. Binding of ligand results in the dimerization of receptor monomers followed by transphosphorylation of tyrosine residues within the cytoplasmic domains of the receptors. This tidy picture has, however, some strange characters lurking around the edges. Cases have now been identified in which RTKs lack kinase activity, but, despite being “dead” appear to have roles in signal transduction. Even stranger are the cases in which genes encoding (...) RTKs produce protein products consisting of only a portion of the kinase domain. At least one such “fractured” RTK appears to be involved in signal transduction. Here we describe how these strange molecules might function and discuss the questions associated with their evolution. BioEssays 23:69–76, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Indexicality, the ability of language to evoke the context in which it usually occurs, is a concept commonly drawn upon in sociolinguistics and linguistic anthropology. This article applies the framework of orders of indexicality to political discourse about a controversial topic in Pittsburgh, United States, the construction of bike lanes. A concordance analysis of the term bike lanes in news media, blogs and online news comments helps to explain the variation in the indexical meanings of bike lanes between those who (...) oppose and those who support bike lanes. We argue that the orders of indexicality approach helps explain how groups with different interests can reinforce or challenge the possible discursive associations of a loaded political term. (shrink)

What obligations and responsibilities, if any, do adult children have with respect to their aged parents? This paper briefly considers the socio‐historical and legal bases for filial obligations and suggests there is a mismatch between perceptions in the community over what they see as their obligations, what policy makers would like to impose and how philosophers identify and ground these obligations. Examining four philosophical models of filial obligation, we conclude that no one account provides an adequate justification for the types (...) of responsibility that might be assumed in a family relationship. (shrink)

It is widely thought that grounding is a hyperintensional phenomenon. Unfortunately, the term ‘hyperintensionality’ has been doing double-duty, picking out two distinct phenomena. This paper clears up this conceptual confusion. We call the two resulting notions hyperintensionalityGRND and hyperintensionalityTRAD. While it is clear that grounding is hyperintensionalGRND, the interesting question is whether it is hyperintensionalTRAD. We argue that given well-accepted constraints on the logical form of grounding, to wit, that grounding is irreflexive and asymmetric, grounding is hyperintensionalTRAD only if one (...) endorses a sentential operator view of grounding. We argue that proponents of the sentential operator view will need to distinguish two importantly different kinds of hyperintensionalityTRAD—weak and strong—and we offer them a way to do so. (shrink)

This paper defends Flatland—the view that there exist neither determination nor dependence relations, and that everything is therefore fundamental—from the objection from explanatory inefficacy. According to that objection, Flatland is unattractive because it is unable to explain either the appearance as of there being determination relations, or the appearance as of there being dependence relations. We show how the Flatlander can meet the first challenge by offering four strategies—reducing, eliminating, untangling and omnizing—which, jointly, explain the appearance as of there being (...) determination relations where no such relations obtain. Since, plausibly, dependence relations just are asymmetric determination relations, we argue that once we come mistakenly to believe that there exist determination relations, the existence of other asymmetries (conceptual and temporal) explains why it appears that there are dependence relations. (shrink)

The established view regarding ‘brain death’ in medicine and medical ethics is that patients determined to be dead by neurological criteria are dead in terms of a biological conception of death, not a philosophical conception of personhood, a social construction or a legal fiction. Although such individuals show apparent signs of being alive, in reality they are dead, though this reality is masked by the intervention of medical technology. In this article, we argue that an appeal to the distinction between (...) appearance and reality fails in defending the view that the ‘brain dead’ are dead. Specifically, this view relies on an inaccurate and overly simplistic account of the role of medical technology in the physiology of a ‘brain dead’ patient. We conclude by offering an explanation of why the conventional view on ‘brain death’, though mistaken, continues to be endorsed in light of its connection to organ transplantation and the dead donor rule. (shrink)

This book contains new essays in honor of Melvin J. Lerner, a pioneer in the psychological study of justice. The contributors to this volume are internationally renowned scholars from psychology, business, and law. They examine the role of justice motivation in a wide variety of contexts, including workplace violence, affirmative action programs, helping or harming innocent victims and how people react to their own fate. Contributors explore fundamental issues such as whether people's interest in justice is motivated by self-interest or (...) a genuine concern for the welfare of others, when and why people feel a need to punish transgressors, how a concern for justice emerges during the development of societies and individuals, and the relation of justice motivation to moral motivation. How an understanding of justice motivation can contribute to the amelioration of major social problems is also examined. (shrink)

The notion of an extended simple region (henceforth ESR) has recently been marshalled in the service of arguments for a variety of conclusions. Exactly how to understand the idea of extendedness as it applies to simple regions, however, has been largely ignored, or, perhaps better, assumed. In this paper we first (§1) outline what we take to be the standard way that philosophers are thinking about extendedness, namely as an intrinsic property of regions. We then introduce an alternative picture (§2), (...) according to which extendedness is extrinsic. In §3 we argue that it matters which way of thinking about extendedness is the right one, since how ESRs behave is sensitive to what extendedness consists in, and various arguments that appeal to ESRs turn out to be unsound if extendedness is extrinsic rather than intrinsic. (shrink)

In memoriam of Vernon Venable, American philosopher who for four decades was a master teacher in the history of Western philosophy, author of an important study of Marx, and the seminal spirit in the development and flourishing of the program in philosophy at Vassar College.

Physical theories often characterize their observables with real number precision. Many non-fundamental theories do so needlessly: they are more precise than they need to be to capture the physical matters of fact about their observables. A natural expectation is that a truly fundamental theory will require its full precision in order to exhaustively capture all of the fundamental physical matters of fact. I argue against this expectation and I show that we do not have good reason to expect that the (...) standard of precision set by successful theories, or even by a truly fundamental theory, will match the granularity of the physical facts. (shrink)

We show 13 stages of the development of tool-use and tool making during different eras in the evolution of Homo sapiens. We used the NeoPiagetian Model of Hierarchical Complexity rather than Piaget's. We distinguished the use of existing methods imitated or learned from others, from doing such a task on one's own.

Quantum field theories containing massless particles are divergent not just in the ultraviolet but also in the infrared. Infrared divergences are typically regarded as less conceptually problematic than ultraviolet divergences because there is a cancellation mechanism that renders measurable physical observables such as decay rates and cross-sections infrared finite. In this article, I scrutinize the restriction to measurable physical observables that is required to arrive at infrared finite results. I argue that the restriction does not necessitate a retreat to operationalism (...) about the meaning of the theory, but it does call attention to underappreciated features of the infrared regime. (shrink)

Haag's theorem has been interpreted as establishing that quantum field theory cannot consistently represent interacting fields. Earman and Fraser have clarified how it is possible to give mathematically consistent calculations in scattering theory despite the theorem. However, their analysis does not fully address the worry raised by the result. In particular, I argue that their approach fails to be a complete explanation of why Haag's theorem does not undermine claims about the empirical adequacy of particular quantum field theories. I then (...) show that such empirical adequacy claims are protected from Haag's result by the techniques that are required to obtain theoretical predictions for realistic experimental observables. I conclude by showing how Haag's theorem is illustrative of a general tension between the foundational significance of results that can be obtained in perturbation theory and non-perturbative characterizations of the content of quantum field theory. (shrink)

Purpose – This paper aims to explore similarities and differences between robots, invasive biological species, and genetically modified organisms. These comparisons are designed to better understand the potential effects of robots on human society. Design/methodology/approach – This paper applies established ideas in one discipline – biology – to issues that are less well understood, but actively being studied in another discipline – science and technology studies. Findings – Robots entering human society in large numbers share many of the characteristics of (...) an invasive species entering a new ecosystem. The authors also find that robots have several characteristics that are similar to a genetically modified organism. Taken together, these similarities suggest that society should be cautious about the introduction of large numbers of robots in a short period of time. Originality/value – The approach taken here to assess robots in society by these analogies to ecological processes is, to the authors' knowledge, novel. Applying ideas from a better-known area to a less well-known area is routine in philosophy, but these particular analogies have not yet been carefully articulated in the literature. (shrink)

Artificial Intelligence (AI) contributes to common goods and common harms in our everyday lives. In light of the Collingridge dilemma, information about both the actual and potential harm of AI is explored and myths about AI are dispelled. Catholic health care is then presented as being in a unique position to exert its influence to model the use of AI systems that minimizes the risk of harm and promotes human flourishing and the common good.

The practice of freedom that is finite, realistically libertarian, and relational is vital for the wholesome development of human beings. In promoting this idea, Michael Miller challenges traditional Christian teachings that have hindered the pursuit of freedom by human beings on the basis of their humanity per se. It also provides theological, ethical, and ecclesiological insights to inspire ventures in freedom and guidance to those who are on the path of freedom.

Drawing on a recent case report of a pregnant, brain‐dead woman who gave birth to a healthy child after over seven months of intensive care treatment, this essay rejects the established doctrine in medicine that brain death constitutes the biological death of the human being. The essay describes three policy options with respect to determination of death and vital organ transplantation in the case of patients who are irreversibly comatose but remain biologically alive.

I present an original model in judgment aggregation theory that demonstrates the general impossibility of consistently describing decision-making purely at the group level. Only a type of unanimity rule can guarantee a group decision is consistent with supporting reasons, and even this possibility is limited to a small class of reasoning methods. The key innovation is that this result holds when individuals can reason in different ways, an allowance not previously considered in the literature. This generalizes judgment aggregation to subjective (...) decision situations, implying that the discursive dilemma persists without individual agreement on the logical constraints. Notably, the model mirrors the typical method of choosing political representatives, and thus suggests that no voting procedure other than unanimity rule can guarantee representation that reflects electorate opinion. Finally, I apply the results to a normative argument for unanimity rule in contract theory and juries, as well as to problems posed for deliberative democratic theory and the concept of representation. (shrink)

In athletics, coaches and athletes share a unique and important relationship. Recently Jowett and her colleagues (Jowett & Cockerill, 2003; Jowett & Meek, 2000; Jowett & Ntoumanis, 2003, 2004; Jowett & Timson-Katchis, 2005) utilized relationship research (focusing on, for example, marital, familial and workplace relationships) from conjoining fields, and in particular social and cognitive psychology, to develop and test a four-component model (4 C’s) that depicts the most influential relational and emotional components (closeness, commitment, complementarity and co-orientation) of coach-athlete relationships. (...) Proceeding from a review of the literature on human touch communication to examine research on the power of touch to exchange relational and emotional messages (Hertenstein et al., 2006), the present study explores coaches’ and athletes’ collective experiences of communicating via touch, utilizing in-depth interviews with eight college coaches and athletes. A phenomenological approach was used to gather, analyze and interpret the data, drawing on Merleau-Ponty’s (1945/1962) philosophical exploration of perception and human experience, which emphasizes the body as a means of communicating with the world. The findings indicate that touch between coaches and athletes increased at major events when emotions and tensions ran high. In addition, touch involved showing appreciation, instructing, comforting and giving attention, and affected perceptions of relationships. The findings also show that touch communication is influenced by societal factors, such as gender, relational stage, and what spectators, parents and other athletes may think. By illustrating how touch is enacted and experienced by a group of college coaches and athletes, the study represents an initial step toward understanding touch communication in the coach-athlete dyad. Indo-Pacific Journal of Phenomenology , Volume 7, Edition 2 September 2007. (shrink)

My topic is authenticity in or perhaps as painting, not the authenticity of paintings; I know next to nothing about the problem of verifying claims of authorship. I am interested in another kind of genuineness and fraudulence, the kind at issue when we say of a person that he or she is false, not genuine, inauthentic, lacks integrity, and, especially when we say he or she is playing to the crowd, playing for effect, or is a poseur. These are not (...) quite moral distinctions (no one has a duty to be authentic), but they are robustly normative appraisals, applicable even when such falseness is not a case of straight hypocrisy but of lack of self-knowledge or of self-deceit. (A person can be quite sincere and not realize the extent of her submission to the other’s expectations and demands.) This sort of appraisal also has a long history in post-Rousseauist reflections on the dangers of uniquely modern forms of social dependence, and they are prominent worries in the modern novel. (shrink)

Approaches to the interpretation of physical theories provide accounts of how physical meaning accrues to the mathematical structure of a theory. According to many standard approaches to interpretation, meaning relations are captured by maps from the mathematical structure of the theory to statements expressing its empirical content. In this article I argue that while such accounts adequately address meaning relations when exact models are available or perturbation theory converges, they do not fare as well for models that give rise to (...) divergent perturbative expansions. Since truncations of divergent perturbative expansions often play a critical role in establishing the empirical adequacy of a theory, this is a serious deficiency. I show how to augment state-space semantics, a view developed by Beth and van Fraassen, to capture perturbatively evaluated observables even in cases where perturbation theory is divergent. This new semantics establishes a sense in which the calculations that underwrite the empirical adequacy of a theory are both meaningful and true, but requires departure from the assumption that physical meaning is captured entirely by the exact models of a theory. (shrink)

Steve Paulson, executive producer and host of To the Best of Our Knowledge, moderated a discussion with philosopher Christian Miller, neuroscientist Heather Berlin, and historian of science Michael Shermer to examine our moral ecology and its influence on our underlying assumptions about human nature.

This is a description of an avian-shaped feature that rests below a network of cellular structures found on a mound within the Argyre Basin of Mars in Mars Global Surveyor image M14-02185, acquired on April 30, 2000, and released to the public on April 4, 2001. The area examined is located near 48.0° South, 55.1° West. The formation is approximately 2,400 meters long from the tip of its beak to the tip of its farthest tail feather. There is a minimum (...) of six different variations in appearance of the surface material over this small area. Utilizing the public targeting request form provided on the Mars Global Surveyor (MGS) website, co-author Miller secured a second image of the area that was obtained on July 3, 2006, showing this feature under different conditions S20-00165. The new image was then released to the public on August 11, 2006. A third image of the formation identified as MGS S13-01480 was acquired on December 15, 2005, and although officially processed on June 20, 2006, it was not made available to the public until August 22, 2009, on NASA’s Planetary Data System (PDS) website. All three of the MGS images reveal defining aspects of this avian feature, including a head, beak, body, eye, leg, foot, toes, wing, and feathers. When taken together, these components induce the visual impression of an avian-shaped formation that exhibits a unique set of proportional features. Adjoining this formation is a composite of complex cellular features that form a compartmentalized infrastructure. The three authors who are veterinarians provide a critical analysis of the avian features, and the geologist and geoscientist authors examine natural mechanisms that could contribute to the formation of this feature. An extensive search of comparable regions within and beyond the area of the Argyre Basin was conducted. A list of these sites is provided, and terrestrial comparisons are also offered. (shrink)

This paper analyzes individual probabilistic predictions of state outcomes in the 2008 U.S. presidential election. Employing an original survey of more than 19,000 respondents, ours is the first study of electoral forecasting to involve multiple subnational predictions and to incorporate the influence of respondents’ home states. We relate a range of demographic, political, and cognitive variables to individual accuracy and predictions, as well as to how accuracy improved over time. We find strong support for wishful thinking bias in expectations, as (...) Republicans gave higher probabilities to McCain victories and were worse at overall prediction. In addition, we find that respondents living in states with higher vote shares for Obama performed better at prediction and displayed less wishful thinking bias. We conclude by showing that suitable aggregations of our respondents’ predictions outperformed Intrade (a prediction market) and fivethirtyeight.com (a poll-based forecast) at most points in time. (shrink)

The goal of this article is to outline a new account of the virtue of patience. To help build the account, we focus on five important issues pertaining to patience: (i) goals and time, (ii) emotion, (iii) continence versus virtue, (iv) motivation, and (v) good ends. The heart of the resulting account is that patience is a cross-situational and stable disposition to react, both internally and externally, to slower than desired progress toward goal achievement with a reasonable level of calmness. (...) The article ends with an application of the account to better understanding the vices associated with patience. (shrink)

This is the first-ever book on Michael Walzer's ground-breaking and widely studied book Spheres of Justice. It contains contributions from many of the world's leading political philosophers.

The dual-use dilemma arises in the context of research in the biological and other sciences as a consequence of the fact that one and the same piece of scientific research sometimes has the potential to be used for bad as well as good purposes. It is an ethical dilemma since it is about promoting good in the context of the potential for also causing harm, e.g., the promotion of health in the context of providing the wherewithal for the killing of (...) innocents. It is an ethical dilemma for the researcher because of the potential actions of others, e.g., malevolent non-researchers who might steal dangerous biological agents, or make use of the original researcher’s work. And it is a dilemma for governments concerned with the security of their citizens, as well as their health. In this article we construct a taxonomy of types of “experiments of concern” in the biological sciences, and thereby map the terrain of ethical risk. We then provide a series of analyses of the ethical problems and considerations at issue in the dual-use dilemma, including the impermissibility of certain kinds of research and possible restrictions on dissemination of research results given the risks to health and security. Finally, we explore the main available institutional responses to some of the specific ethical problems posed by the dual-use dilemma in the biological sciences. (shrink)

This paper places Julian Schwinger's development of the Euclidean Green's function formalism for quantum field theory in historical context. It traces the techniques employed in the formalism back to Schwinger's work on waveguides during World War II, and his subsequent formulation of the Minkowski space Green's function formalism for quantum field theory in 1951. Particular attention is dedicated to understanding Schwinger's physical motivation for pursuing the Euclidean extension of this formalism in 1958.

We apply a cognitive modeling approach to the problem of measuring expertise on rank ordering problems. In these problems, people must order a set of items in terms of a given criterion (e.g., ordering American holidays through the calendar year). Using a cognitive model of behavior on this problem that allows for individual differences in knowledge, we are able to infer people's expertise directly from the rankings they provide. We show that our model-based measure of expertise outperforms self-report measures, taken (...) both before and after completing the ordering of items, in terms of correlation with the actual accuracy of the answers. These results apply to six general knowledge tasks, like ordering American holidays, and two prediction tasks, involving sporting and television competitions. Based on these results, we discuss the potential and limitations of using cognitive models in assessing expertise. (shrink)

One of the most powerful traditions of the Jewish fascination with language is that of the Name. Indeed, the Jewish mystical tradition would seem a two millennia long meditation on the nature of name in relation to object, and how name mediates between subject and object. Even within the tide of the 20th century's linguistic turn, the aspect most notable in - the almost entirely secular - Jewish philosophers is that of the personal name, here given pivotal importance in the (...) articulation of human relationships and dialogue. The Name of God in Jewish Thought examines the texts of Judaism pertaining to the Name of God, offering a philosophical analysis of these as a means of understanding the metaphysical role of the name generally, in terms of its relationship with identity. The book begins with the formation of rabbinic Judaism in Late Antiquity, travelling through the development of the motif into the Medieval Kabbalah, where the Name reaches its grandest and most systematic statement - and the one which has most helped to form the ideas of Jewish philosophers in the 20th and 21st Century. This investigation will highlight certain metaphysical ideas which have developed within Judaism from the Biblical sources, and which present a direct challenge to the paradigms of western philosophy. Thus a grander subtext is a criticism of the Greek metaphysics of being which the west has inherited, and which Jewish philosophers often subject to challenges of varying subtlety; it is these philosophers who often place a peculiar emphasis on the personal name, and this emphasis depends on the historical influence of the Jewish metaphysical tradition of the Name of God. Providing a comprehensive description of historical aspects of Jewish Name-Theology, this book also offers new ways of thinking about subjectivity and ontology through its original approach to the nature of the name, combining philosophy with text-critical analysis. As such, it is an essential resource for students and scholars of Jewish Studies, Philosophy and Religion. (shrink)

ABSTRACT Certain problems in commonsense reasoning lend themselves to the use of non-standard formalisms which we call active logics. Among these are problems of objects misidentification. In this paper we describe some technical issues connected with automated inference in active logics, using particular object misidentification problems as illustrations. Control of exponential growth of inferences is a key issue. To control this growth attention is paid to a limited version of an inference rule for negative introspection. We also present some descriptive (...) statistics for comparison with earlier active-logic approaches. (shrink)

Haag’s theorem has been interpreted as establishing that quantum field theory cannot consistently represent interacting fields. Earman and Fraser have clarified how it is possible to give mathematically consistent calculations in scattering theory despite the theorem. However, their analysis does not fully address the worry raised by the result. In particular, I argue that their approach fails to be a complete explanation of why Haag’s theorem does not undermine claims about the empirical adequacy of particular quantum field theories. I then (...) show that such empirical adequacy claims are protected from Haag’s result by the techniques that are required to obtain theoretical predictions for realistic experimental observables. I conclude by showing how Haag’s theorem is illustrative of a general tension between the foundational significance of results that can be obtained in perturbation theory and non-perturbative characterizations of the content of quantum field theory. 1 Introduction2 Haag’s Theorem and the Interaction Picture3 Earman and Fraser on the Success of Scattering Theory4 Haag’s Theorem and Empirical Adequacy5 Conclusion. (shrink)

Science and technology are so intertwined that technoscience has been argued to more accurately reflect the progress of science and its impact on society, and most socioscientific issues require technoscientific reasoning. Education policy documents have long noted that the general public lacks sufficient understanding of science and technology necessary for informed decision-making regarding socioscientific/technological issues. The science–technology–society movement and scholarship addressing socioscientific issues in science education reflect efforts in the science education community to promote more informed decision-making regarding such issues. (...) Now Science, Technology, Engineering, Mathematics education has emerged as a major reform movement impacting science education. STEM education efforts emphasize literacy across the disciplines of science, technology, engineering, and mathematics, but with rare exceptions, treat issues of technology superficially and uncritically. Informed decision-making regarding many personal and societal issues requires technological literacy beyond merely becoming an enthusiastic designer or skilled user of technology, but the science education community has given little attention to what such literacy entails. Here, we present results of an extensive review of the literature regarding the nature of technology in order to identify key issues among scholars who study technology. We then provide predominant perspectives among those scholars and suggest which identified NOT issues are most essential to address as part of STEM education efforts that seek to promote informed personal and societal decision-making. (shrink)